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every patient into the same basket. One risk with the

presented nomogram is that it includes androgen deprivation

therapy use as a factor

a subjective measure which is a

surrogate for other disease factors not measured in the

nomogram. Postoperative PSA velocity is not taken into

account. These patients come from a long-time period, much

of which was a different era in terms of the clinical risk

groups of patients undergoing prostatectomy. The study

offers valuable insight that not all men with a residual PSA

after prostatectomy require immediate additional treatment,

but they still require complex consideration of many

variables in making a recommendation for or against salvage

radiotherapy.

Conflicts of interest:

Koontz receives unrestricted research funding from

Janssen Pharmaceuticals, and is an advisory board member for Blue

Earth Diagnostics.

References

[1]

Bolla M, van Poppel H, Tombal B, et al. Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911). Lancet 2012;380:2018 27

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[2]

Thompson IM, Tangen CM, Paradelo J, et al. Adjuvant radiotherapy for pathological T3N0M0 prostate cancer signi fi cantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial. J Urol 2009;181:956 62

.

[3]

Wiegel T, Bartkowiak D, Bottke D, et al. Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96-02/AUO AP 09/95 trial. Eur Urol 2014;66:243 50

.

[4]

Tendulkar RD, Agrawal S, Gao T, et al. Contemporary update of a multi-institutional predictive nomogram for salvage radiotherapy after radical prostatectomy. J Clin Oncol 2016;34:3648 54.

[5]

Gandaglia G, Boorjian SA, Parker WP, et al. Impact of postoperative radiotherapy in men with persistently elevated prostate-speci fi c antigen after radical prostatectomy for prostate cancer: a long-term survival analysis. Eur Urol 2017;72:910 7

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[6]

Tetlock PE. Expert political judgment: how good is it? How can we know?. Princeton, NJ: Princeton University Press; 2005.

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