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Author contributions:

Liam Bourke had full access to all the data in the

study and takes responsibility for the integrity of the data and the

accuracy of the data analysis.

Study concept and design:

Bourke.

Acquisition of data:

Bourke, Lardas, Liew.

Analysis and interpretation of data:

Bourke, Lardas, Liew.

Drafting of the manuscript:

Lardas.

Critical revision of the manuscript for important intellectual content:

van

den Bergh, De Santis, Bellmunt, Van den Broeck, Cornford, Cumberbatch,

Fossati, Gross, Henry, Bolla, Briers, Joniau, Lam, Mason, Mottet, van der

Poel, Rouvie`re, Schoots, Wiegel, Willemse, Yuan.

Statistical analysis:

None.

Obtaining funding:

None.

Administrative, technical, or material support:

None.

Supervision:

Bourke.

Other:

None.

Financial disclosures:

Liam Bourke certifies that all conflicts of interest,

including specific financial interests and relationships and affiliations

relevant to the subject matter or materials discussed in the manuscript

(eg, employment/affiliation, grants or funding, consultancies, honorar-

ia, stock ownership or options, expert testimony, royalties, or patents

filed, received, or pending), are the following: Maria De Santis is a

company consultant for GlaxoSmithKline, Janssen, Bayer, Novartis,

Pierre Fabre, Astellas, Amgen, Eisai, ESSA, Merck, and Synthon; has

received company speaker honoraria from Pfizer, Takeda, Sanofi

Aventis, Shionogi, Celgene, and Teva OncoGenex; has participated in

trials for Pierre Fabre, Astellas, Exelixis, Bayer, and Roche; has received

fellowship and travel grants from Bayer, Novartis, Ferring, Astellas,

Sanofi Aventis, and Janssen; has received grant and research support

from Pierre Fabre; has received honoraria from AstraZeneca; and is

associated with Amgen. Joaquim Bellmunt is a company consultant for

Janssen, Astellas, Pierre Fabre, Genentech, Merck, Ipsen, Pfizer,

Novartis, and Sanofi Aventis, and has received research support from

Takeda, Novartis, and Sanofi, and travel grants from Pfizer and Pierre

Fabre. Philip Cornford is a company consultant for Astellas, Ipsen, and

Ferring; receives company speaker honoraria from Astellas, Janssen,

Ipsen, and Pfizer; participates in trials from Ferring; and receives

fellowships and travel grants from Astellas and Janssen. Malcolm D.

Mason is a company consultant for Bristol-Myers Squibb, Janssen,

Bayer, Sanofi, and Dendreon, and receives company speaker honoraria

from Takeda and Bayer. Michel Bolla has received company speaker

honoraria from Ipsen and Astellas, honoraria or consultation fees from

Janssen, and fellowship and travel grants from Janssen, AstraZeneca,

and Astellas. Erik Briers has received grant and research support from

the European Association of Urology; is an ex officio board member for

Europa UOMO; is an ethics committee and advisory group member for

REQUITE; is a patient advisory board member for PAGMI; and is a

member of SCA and EMA PCWP. Steven Joniau is a company consultant

for Astellas, Ipsen, Bayer, Sanofi, and Janssen; has received company

speaker honoraria from Astellas, Amgen, Bayer, Sanofi, Janssen, and

Ipsen; has participated in trials for Astellas, Janssen, and Bayer; has

received fellowship and travel grants from Astellas, Amgen, Bayer,

Sanofi, Janssen, Ipsen, and Pfizer; and has received grant and research

support from Astellas, Bayer, and Janssen. Thomas B. Lam is a company

consultant for and has received company speaker honoraria fromPfizer,

GSK, Astellas, and Ipsen. MalcolmD. Mason is a company consultant for

Bristol-Myers Squibb, Janssen, Bayer, Sanofi, and Dendreon, and receives

company speaker honoraria from Takeda and Bayer. Nicolas Mottet has

received grant and research support from Takeda Pharmaceutical,

Millenium, Astellas, Pierre Fabre, Sanofi, and Pasteur, and has received

honoraria or consultation fees from Takeda Pharmaceutical, Millennium,

Jansen, Astellas, BMS, Bayer, Ipsen, Ferring, Novartis, Nucle´tron, Pierre

Fabre, Sanofi, and Zeneca. Henk G. van der Poel is a company consultant

for Intuitive Surgical, has participated in trials for Astellas and Steba

Biotech, and has received grant and research support from Astellas.

Olivier Rouvie`re is a company consultant for EDAP-TMS, Bracco, and

Philips; has received company speaker honoraria from EDAP-TMS, Bracco,

and Philips; and has participated in trials for EDAP-TMS and Bracco.

Thomas Wiegel has received company speaker honoraria from Astellas,

Takeda, Hexal, Ipsen, Janssen-Cilac, and Ferring. Michael Lardas, Matthew

Liew, Roderick C.N. van den Bergh, Thomas Van den Broeck, Marcus G.

Cumberbatch, Nicola Fossati, Tobias Gross, Ann M. Henry, Ivo G. Schoots,

Peter-Paul M. Willemse, Cathy Yuhong Yuan, and Liam Bourke have

nothing to disclose.

Funding/Support and role of the sponsor:

None.

Appendix B. Supplementary data

Supplementary data associated with this article can be

found, in the online version, at

http://dx.doi.org/10.1016/j. eururo.2017.06.035 .

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