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in 10 (44%) patients. While routine use of CT may expose the

patient to unnecessary radiation exposure, it remains the

most sensitive study to determine complete stone clearance,

and it is possible that in patients undergoing ultrasound, a

small RF could have been missed. In the one patient where

stone clearance was incomplete (3 mm lower pole RF

detected on CT), it was when a concomitant lower pole

stone could not be identified and retrieved with the flexible

nephroscope. While it is important to assess the kidney for

residual stones with ultrasound, and flexible nephroscopy

can be used to retrieve stones, we consider RPL and RNL

better suited for patients with single stones to avoid these

issues. Further, this was a retrospective study, and as such

has the potential for reporting bias. Finally, our follow-up is

not long enough to assess repeat stone episodes or

interventions, which is an important marker for outcomes.

We also emphasize that the indication to perform robotic

surgery needs to take into account factors such as risk of

recurrence, and consequences of any re-do surgery in the

future. However, even in pediatric patients, robotic surgery

for kidney stones has been found to be safe and effective

[24]

.

It is yet to be fully determined whether the da Vinci

system will have a significant role to play in the

management of complex stone disease. For the individual

urologist, utilization is likely to be based on the relationship

between three specific factors: skillset, logistics, and cost

[26]

. Obtaining percutaneous access can be quite challeng-

ing, and is one reason why the majority of urologists rely on

radiologists to get access

[31]

. It is likely that the next

generation of urologists will be more comfortable and

skilled with robotics than at gaining percutaneous access.

Regarding logistical factors and access to equipment—

especially if the urologist has to rely on a radiologist—the

urologist is self-sufficient with robotics. However, there is

no doubt that robotics has high capital and instrument

costs, and in some centers which are not high-volume

robotic centers or do not have a robot it will be more

sensible to perform laparoscopy in these select patients.

Finally, further studies are required to determine the

efficacy of robotic surgery in comparison to the standard

of PCNL. A randomized controlled trial assessing the

comparative effectiveness of each procedure in respect to

SFR, morbidity and long-term retreatment may help define

future treatment algorithms.

5.

Conclusion

RPL and RNL are safe and reasonable options for removing

large renal stones in select patients and for surgeons

experienced and comfortable with robotic kidney surgery.

RPL is ideal for single pelvic or partial staghorn stones,

whereas RNL is suitable for calyceal stones if the overlying

parenchyma is thin, providing a bloodless window into the

kidney. Advantages of both techniques include low risk of

sepsis and bleeding. More importantly, the robotic ap-

proach permits zero-fragment nephrolithotomy where the

stone is removed in toto thereby maximizing chances for

complete stone clearance, and avoiding the pitfall of future

retreatment due to retained fragments.

Author contributions

: Khurshid R. Ghani had full access to all the data in

the study and takes responsibility for the integrity of the data and the

accuracy of the data analysis.

Study concept and design:

[11_TD$DIFF]

Ghani, Madi, Elder, Hemal

[4_TD$DIFF]

, Badani.

Acquisition of data:

Swearingen, Sood,

[12_TD$DIFF]

Madi, Klaassen, Badani, Elder,

Wood, Hemal, Ghani.

Analysis and interpretation of data:

[13_TD$DIFF]

Ghani, Swearingen, Sood.

Drafting of the manuscript:

[14_TD$DIFF]

Ghani, Swearingen.

Critical revision of the manuscript for important intellectual content:

[15_TD$DIFF]

Madi,

Elder, Hemal, Badani, Ghani.

Statistical analysis:

Swearingen.

Obtaining funding:

Ghani.

Administrative, technical, or material support:

Ghani, Madi, Badani, Elder,

Hemal.

Supervision:

Ghani.

Other:

None.

Financial disclosures:

Khurshid R. Ghani certifies that all conflicts of

interest, including specific financial interests and relationships

and affiliations relevant to the subject matter or materials discussed in

the manuscript (eg, employment/affiliation, grants or funding,

consultancies, honoraria, stock ownership or options, expert testimony,

royalties, or patents filed, received, or pending), are the following:

None.

Funding/Support and role of the sponsor:

None.

Appendix A. Supplementary data

The Surgery in Motion video accompanying this article

can be found in the online version at

http://dx.doi.org/10. 1016/j.eururo.2016.10.021

and via

www.europeanurology. com .

References

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