872 1030
Importantly, the study reported no difference in EORTC
QLQ-C30–assessed global QoL, up to 5 yr of follow-up.
However, Expanded Prostate Cancer Index Composite
(EPIC) urinary summary scores were worse in men treated
with RP compared with active monitoring or EBRT (88.7 vs
89.0 vs 91.4, respectively) as were urinary incontinence
(80.9 vs 85.8 vs 89.4, respectively) and sexual summary,
function, and bother scores (32.3 vs 40.6 vs 41.3 for sexual
summary, 23.7 vs 32.5 vs 32.7 for sexual function, and
51.4 vs 57.9 vs 60.1 for sexual bother, respectively) at 6 yr of
follow-up. For men receiving EBRT, EPIC bowel scores
deteriorated initially, and although they improved after the
1st year, they were still poorer compared with active
monitoring and RP at 6 yr post-treatment in all domains:
summary (91.2 vs 93.2 vs 93.0, respectively), function
(90.8 vs 92.3 vs 92.3, respectively), and bother (91.7 vs
94.2 vs 93.7, respectively).
3.4.1.2. RP versus BT.
For the comparison of RP versus BT, data
were obtained from two RCTs. The Surgical Prostatectomy
[(Fig._1)TD$FIG]
Abstracts and titles screened
(
n
=12 420)
Articles identified for full-
text screening (
n
= 130)
Records excluded
(
n
= 12 290)
Articles full-text
screened (
n
= 130)
Studies excluded (
n
=110)
•
2 theses/reviews
•
1 article reporting study
design
•
12 using a nonvalidated
patient-reported
outcome questionnaire
•
5 studies not reporting
all domains of cancer-
specific QoL
questionnaire
•
9 retrospective studies
•
17 no outcomes by
intervention
•
34 include patients with
nonclinically localised
PCa
•
1 not comparative
•
1 <10 participants per
arm
•
24 no eligible
comparator
•
2 follow-up <12 mo
•
2 authors contacted but
did not respond
regarding raw data
18 studies included
(
n
= 20 reports)
Abstracts and titles identified
through database searching
(
n
= 12 420)
Fig. 1 – PRISMA flow diagram. QoL = quality of life; PCa = prostate cancer; PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-
analyses.
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 8 6 9 – 8 8 5
872