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appropriate IsoPSA cutoff for discriminating patients with
high-grade versus benign/low-grade prostate cancer.
The important point is to keep in mind that the most
appropriate cutoff value for each test changes from
population to population, depending on the prior probabil-
ity of the disease of interest and the costs of a false-negative
relative to a false-positive test result. The cutoff point can
easily be found by maximizing wNNM
[2–4].
Conflicts of interest:
The authors have nothing to disclose.
References
[1]
Klein EA, Chait A, Hafron JM, et al. The single-parameter, structure- based IsoPSA assay demonstrates improved diagnostic accuracy for detection of any prostate cancer and high-grade prostate cancer compared to a concentration-based assay of total prostate-specific antigen: a preliminary report. Eur Urol 2017;72:942–9.
[2]
Habibzadeh F, Habibzadeh P, Yadollahie M. On determining the most appropriate test cut-off value: the case of tests with continu- ous results. Biochem Med (Zagreb) 2016;26:297–307.[3] Habibzadeh F, Habibzadeh P, Yadollahie M. Criterion used for
determination of test cut-off value. Diabetes Res Clin Pract
2017;128:138–9
. http://dx.doi.org/10.1016/j.diabres.2017.01.011 .[4]
Habibzadeh F, Yadollahie M. Number needed to misdiagnose: a measure of diagnostic test effectiveness. Epidemiology 2013; 24:170.
[5]
Habibzadeh P, Yadollahie M, Habibzadeh F. What is a ‘‘diagnostic test reference range’’ good for? Eur Urol 2017;72:859–60.
Parham Habibzadeh
a
Farrokh Habibzadeh
a,b,
*
a
Shiraz University of Medical Sciences, Shiraz, Iran
b
R&D Headquarters, Petroleum Industry Health Organization, Shiraz, Iran
*Corresponding author. Shiraz University of Medical Sciences, P.O. Box:
71955-575, Shiraz 71955, Iran. Tel./Fax: +98 71 32252258.
E-mail address:
farrokh.habibzadeh@theijoem.com(F. Habibzadeh).
June 21, 2017
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