

cancer. J Clin Oncol 2005;23:7897–903
. http://dx.doi.org/10.1200/ JCO.2004.00.6908 .[4] Shahinian VB, Kuo Y-F, Freeman JL, Goodwin JS. Risk of fracture after
androgen deprivation for prostate cancer. N Engl J Med
2005;352:154–64
. http://dx.doi.org/10.1056/NEJMoa041943.
[5] Thorstenson A, Bratt O, Akre O, et al. Incidence of fractures causing
hospitalisation in prostate cancer patients: results from the popu-
lation-based PCBaSe Sweden. Eur J Cancer 2012;48:1672–81.
http://dx.doi.org/10.1016/j.ejca.2012.01.035.
[6] Tsai HK, D’Amico AV, Sadetsky N, Chen M-H, Carroll PR. Androgen
deprivation therapy for localized prostate cancer and the risk of
cardiovascular mortality. J Natl Cancer Inst 2007;99:1516–24.
http://dx.doi.org/10.1093/jnci/djm168.
[7] Saigal CS, Gore JL, Krupski TL, Hanley J, Schonlau M, Litwin MS.
Androgen deprivation therapy increases cardiovascular morbidity
inmen with prostate cancer. Cancer 2007;110:1493–500.
http://dx. doi.org/10.1002/cncr.22933.
[8] Efstathiou JA, Bae K, Shipley WU, et al. Cardiovascular mortality and
duration of androgen deprivation for locally advanced prostate
cancer: analysis of RTOG 92-02. Eur Urol 2008;54:816–23.
http://dx.doi.org/10.1016/j.eururo.2008.01.021.
[9] Albini A, Pennesi G, Donatelli F, Cammarota R, De Flora S, Noonan
DM. Cardiotoxicity of anticancer drugs: the need for cardio-oncol-
ogy and cardio-oncological prevention. J Natl Cancer Inst
2010;102:14–25
. http://dx.doi.org/10.1093/jnci/djp440 .[10] Hayes JH, Chen M-H, Moran BJ, et al. Androgen-suppression therapy
for prostate cancer and the risk of death in men with a history of
myocardial infarction or stroke. BJU Int 2010;106:979–85
. http:// dx.doi.org/10.1111/j.1464-410X.2010.09273.x.
[11] Robinson D, Garmo H, Lindahl B, et al. Ischemic heart disease and
stroke before and during endocrine treatment for prostate cancer in
PCBaSe Sweden. Int J Cancer 2012;130:478–87
. http://dx.doi.org/ 10.1002/ijc.26022 .[12] O’Farrell S, Garmo H, Holmberg L, Adolfsson J, Stattin P, Van
Hemelrijck M. Risk and timing of cardiovascular disease after
androgen-deprivation therapy in men with prostate cancer. J Clin
Oncol 2015;33:1243–51
. http://dx.doi.org/10.1200/jco.2014.59. 1792.
[13] Van Hemelrijck M, Garmo H, Holmberg L, et al. Absolute and
relative risk of cardiovascular disease in men with prostate cancer:
results from the population-based PCBaSe Sweden. J Clin Oncol
2010;28:3448–56
. http://dx.doi.org/10.1200/JCO.2010.29.1567.
[14] Keating NL, O’Malley AJ, Smith MR. Diabetes and cardiovascular
disease during androgen deprivation therapy for prostate cancer. J
Clin Oncol 2006;24:4448–56
. http://dx.doi.org/10.1200/JCO.2006. 06.2497 .[15] Braga-Basaria M, Dobs AS, Muller DC, et al. Metabolic syndrome in
men with prostate cancer undergoing long-term androgen-depri-
vation therapy. J Clin Oncol 2006;24:3979–83
. http://dx.doi.org/10. 1200/JCO.2006.05.9741.
[16] Crawley D, Garmo H, Rudman S, et al. Association between duration
and type of androgen deprivation therapy and risk of diabetes in
men with prostate cancer. Int J Cancer 2016;139:2698–704
. http:// dx.doi.org/10.1002/ijc.30403 .[17] Sun M, Choueiri TK, Hamnvik O-PR, et al. Comparison of gonado-
tropin-releasing hormone agonists and orchiectomy: effects of
androgen-deprivation therapy. JAMA Oncol 2016;2:500–7.
http://dx.doi.org/10.1001/jamaoncol.2015.4917 .[18] Jespersen CG, Nørgaard M, Borre M. Androgen-deprivation therapy
in treatment of prostate cancer and risk of myocardial infarction
and stroke: a nationwide Danish population-based cohort study.
Eur Urol 2014;65:704–9
. http://dx.doi.org/10.1016/j.eururo.2013. 02.002.
[19] Teoh JY, Chan SY, Chiu PK, et al. Risk of cardiovascular thrombotic
events after surgical castration versus gonadotropin-releasing hor-
mone agonists in Chinese men with prostate cancer. Asian J Androl
2014;17:493–6
. http://dx.doi.org/10.4103/1008-682X.143313.
[20]
Greenland S, Morgenstern H. Ecological bias, confounding, and effect modification. Int J Epidemiol 1989;18:269–74.[21] Wakefield J. Ecologic studies revisited. Annu Rev Public Health
2008;29:75–90
. http://dx.doi.org/10.1146/annurev.publhealth.29. 020907.090821 .[22] Eloranta S, Adolfsson J, Lambert PC, et al. How can we make cancer
survival statistics more useful for patients and clinicians: an
illustration using localized prostate cancer in Sweden. Cancer
Causes Control 2013;24:505–15
. http://dx.doi.org/10.1007/ s10552-012-0141-5.
[23] Van Hemelrijck M, Wigertz A, Sandin F, et al. Cohort profile: the
National Prostate Cancer Register of Sweden and Prostate Cancer
Data Base Sweden 2.0. Int J Epidemiol 2013;42:956–67
. http://dx. doi.org/10.1093/ije/dys068 .[24] Van Hemelrijck M, Garmo H, Wigertz A, Nilsson P, Stattin P. Cohort
profile update: the National Prostate Cancer Register of Sweden and
Prostate Cancer Data Base—a refined prostate cancer trajectory. Int
J Epidemiol 2015;45:73–82
. http://dx.doi.org/10.1093/ije/dyv305.
[25] Tomic K, Berglund A, Robinson D, et al. Capture rate and represen-
tativity of the National Prostate Cancer Register of Sweden. Acta
Oncol 2015;54:158–63
. http://dx.doi.org/10.3109/0284186X. 2014.939299.
[26] Tomic K, Sandin F, Wigertz A, Robinson D, Lambe M, Stattin P.
Evaluation of data quality in the National Prostate Cancer Register
of Sweden. Eur J Cancer 2015;51:101–11
. http://dx.doi.org/10. 1016/j.ejca.2014.10.025.
[27]
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: devel- opment and validation. J Chronic Dis 1987;40:373–83.
[28] Berglund A, Garmo H, Tishelman C, Holmberg L, Stattin P, Lambe M.
Comorbidity, treatment and mortality: a population based cohort
study of prostate cancer in PCBaSe Sweden. J Urol 2011;185:833–9.
http://dx.doi.org/10.1016/j.juro.2010.10.061.
[29] Statistics Sweden. Longitudinal integration database for health
insurance and labour market studies (LISA by Swedish acronym).
www.scb.se/en_/Services/Guidance-for-researchers-and-universi- ties/SCB-Data/Longitudinal-integration-database-for-health-in- surance-and-labour-market-studies-LISA-by-Swedish-acronym[30] Fall K, Stromberg F, Rosell J, et al. Reliability of death certificates in
prostate cancer patients. Scand J Urol Nephrol 2008;42:352–7.
http://dx.doi.org/10.1080/00365590802078583.
[31] Godtman R, Holmberg E, Stranne J, Hugosson J. High accuracy of
Swedish death certificates in men participating in screening for
prostate cancer: a comparative study of official death certificates
with a cause of death committee using a standardized algorithm.
Scand J Urol Nephrol 2011;45:226–32
. http://dx.doi.org/10.3109/ 00365599.2011.559950 .[32]
Fine P, Gray R. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999;94:496–509.[33] Thie´baut ACM, Be´nichou J. Choice of time-scale in Cox’s model
analysis of epidemiologic cohort data: a simulation study. Stat Med
2004;23:3803–20
. http://dx.doi.org/10.1002/sim.2098.
[34] Ludvigsson JF, Andersson E, Ekbom A, et al. External review and
validation of the Swedish national inpatient register. BMC Public
Health 2011;11:450.
http://dx.doi.org/10.1186/1471-2458- 11-450 .[35]
Johansson LA, Westerling R. Comparing Swedish hospital discharge records with death certificates: implications for mortality statistics. Int J Epidemiol 2000;29:495–502.
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