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adverse pathologic features. Eur Urol. In press.

https://doi.org/10. 1016/j.eururo.2017.03.036 .

[2]

Austin PC, Steyerberg EW. Predictive accuracy of risk factors and markers: a simulation study of the effect of novel markers on different performance measures for logistic regression. Stat Med 2013;32:661–72

.

[3]

Pepe MS, Kerr KF, Longton G, Wang Z. Testing for improvement in prediction model performance. Stat Med 2013;32:1467–82.

[4]

Steyerberg EW, Pencina MJ, Lingsma HF, Kattan MW, Vickers AJ, Van Calster B. Assessing the incremental value of diagnostic and prognostic markers: a review and illustration. Eur J Clin Invest 2012;42:216–28

.

Bruce J. Trock

a

R. Jeffrey Karnes

b,

*

a

James Buchanan Brady Urological Institute and Department of Urology,

Johns Hopkins School of Medicine, Baltimore, MD, USA

b

Department of Urology, Mayo Clinic, Rochester, MN, USA

*Corresponding author. Department of Urology, Mayo Clinic Rochester,

MN 55905, USA.

E-mail address:

karnes.r@mayo.edu

(R.J. Karnes).

May 17, 2017

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